Learn how to draft your nursing resignation letter using our samples, tips and templates. You should give your letter of resignation to your immediate supervisor.How do I format a resignation letter? I am writing to inform you of my resignation as a Registered Nurse at St. Joseph's Nursing Center. My last day of work will be January 19, 2022. Use one of our resignation letter templates. The complete guide to writing a nursing resignation letter with tips, examples, and templates. State that you're leaving, and provide the date of your last day. Use an attractive header with your personal contact info, include the recipient's name, company and address, and include the date. Something like "Jane Doe Resignation Letter" should work.