How to write a resignation letter that's effective immediately? The complete guide to writing your resignation letter including expert tips, free copyable samples, and templates.When resigning without notice, your letter should state clearly that the resignation will be effective immediately. It should include your name, job title, notice of resignation, and your end date. Dear Sir I would like to resign from my job with immediate effect. (For example, "I regret to inform you that I will be resigning from my position, effective immediately. In the Matter of the Accusation. Against: Mychael Luu, M.D.. Physician's and Surgeon's. We don't like it that. LOCATION: San Francisco, CA 94110.