Learn how to draft your nursing resignation letter using our samples, tips and templates. How should I structure my resignation letter?The complete guide to writing a nursing resignation letter with tips, examples, and templates. Use one of our resignation letter templates. Are you gearing up for an exciting new chapter as a registered nurse? I regret to inform you that I am resigning from my position as "night shift RN for Nice Hospital". I am writing to inform you of my resignation as a Registered Nurse at St. Joseph's Nursing Center. My last day of work will be January 19, 2022.