In this blog, we are sharing the answers to four of the most commonly asked questions the PA Business OneStop Shop receives about business registration. The PA Business One-Stop Shop Help Center was created to assist businesses and entrepreneurs to start, operate, and grow a business in Pennsylvania.Interested in starting a business in Pennsylvania in 2024? We put together 93 of the best businesses you can start in Pennsylvania today. Discover the steps to start a business in Pennsylvania with our expert guide. To start your business, first choose the appropriate business structure, such as a sole proprietorship, partnership, or corporation. Step 1: Choose a name and business entity. The following is a stepbystep guide that outlines the process of starting a business in Pennsylvania. Starting a business is exciting and challenging whether you are a seasoned entrepreneur or a firsttime business owner. You have your business plan and chose Pennsylvania as your state of operation.