Donations of certain household items and clothing are often tax deductible when you file your income tax return. Use Schedule A (Form 1040) to figure your itemized deductions.Step 1: Complete the taxpayer information section. If you want your deductible charitable contributions you must itemize your donation deduction on Form 1040, Schedule A: Itemized Deductions. Charitable contributions are generally taxdeductible if you itemize. In many cases, charitable donations are tax-deductible. When you donate to a qualifying organization, you can deduct the amount from your taxable income. You can deduct most or all of what you donated just be sure to follow the irs's hard and fast rules to reap tax benefits. Your deduction may be limited. Complete the Virginia LIMITED ITEMIZED DEDUCTION WORKSHEET below.