To reap tax benefits for making charitable donations, you must itemize your deductions rather than taking the Standard Deduction. Donations of certain household items and clothing are often tax deductible when you file your income tax return.In many cases, charitable donations are tax-deductible. When you donate to a qualifying organization, you can deduct the amount from your taxable income. Charitable donations may be tax deductible. Deducting donations can help lower the portion of your income that's taxed, reducing the amount you pay in taxes. Charitable contributions are generally taxdeductible if you itemize. When you itemize your tax deductions on your return, you can take an income tax deduction for a donation to a 501(c)(3) charitable organization. … and reduce the negative impact of the new tax law. An allocation letter for a tax deduction for which they qualify and for which they provided the services under section 179D.