Through our eCommerce initiative, we're creating opportunities for our businesses and entrepreneurs to sell more online and increase their sales. Gov to complete the Pennsylvania Online Business Tax Registration process.If you start an ecommerce business in Pennsylvania then you may also require a sales tax license. 1) Get a vendors license so you can collect sales tax and remit it to the state. Even though eBay now collects and remits the tax, you need to do this anyway. Thinking about starting a business in Pennsylvania? Here's how to set up a business in the Keystone State in 8 simple steps. In other words, if you do business in Pennsylvania, you must charge sales tax based on the tax rate in Pennsylvania, even if your business is located elsewhere. The rise of ecommerce has added new challenges to how sales tax is collected, reported, and paid in Pennsylvania. Everything e-commerce retailers need to know about how to register for, collect and file Pennsylvania sales tax.