Given their high ozone depletion potential, chlorofluorocarbons have been phased out of production. Learn about EPA's efforts to address ozone layer depletion through international treaties and initiatives.This agreement regulated the consumption and production of ozonedepleting compounds. Rules requiring emissions reductions for power plants, vehicles, and other industries should reduce ozone pollution levels in Minnesota. This document should be cited as: World Meteorological Organization (WMO). Scientific Assessment of Ozone Depletion: 2022, GAW Report No. 278,. The Montreal Protocol is often considered to be the single most effective agreement on international environmental protection. Official website of the National Institutes of Health (NIH). NIH is one of the world's foremost medical research centers. Environment - international agreements.