Medication in liquid form is allowed in carry-on bags in excess of 3.4 ounces in reasonable quantities for the flight. Medications in pill or other solid forms must undergo security screening.All prescription medicines are allowed on airplanes, whether in a carry-on or checked bag. 1. Can you take medicine on a plane? You can travel with prescription drugs or medication in both carryon and checked baggage. How to fly with medicine, including how to pack it effectively and the TSA rules you need to know. While you're allowed to bring your prescription medications with you on a flight, it's important to have some sort of documentation with you. Traveling with medication even prescription drugs isn't as simple as packing it. Thankfully, traveling with medication is rarely an issue. Particularly with domestic travel, the TSA is quite lenient about taking prescriptions on planes.