The applicant and the applicant's spouse must be residents of Mississippi to be eligible for homestead exemption benefits. To apply for Homestead Exemption for the first time, you need to come to the Tax Assessor's Office located at 365 Losher Street, Suite 100, Hernando, MS 38632.To qualify for a homestead exemption the residence must be owner occupied. This can provide asset protection from creditors for at least some of house's value. A detailed list of information is required to file the initial application. You will have lost money on one years property tax exemption. These can be filed between January 2nd and April 1st each year. Harrison County is a county located in the U.S. state of Mississippi. Most questions about property appraisal or property tax should be addressed to your county's appraisal district or tax assessor-collector.