The applicant and the applicant's spouse must be residents of Mississippi to be eligible for homestead exemption benefits. To apply for Homestead Exemption for the first time, you need to come to the Tax Assessor's Office located at 365 Losher Street, Suite 100, Hernando, MS 38632.To qualify for a homestead exemption the residence must be owner occupied. She also challenges orders concerning the sale of her residence and disposition of her homestead exemption that were entered in 2020 and. Download PDF BOE-266 REV.