In this heart surgery, the surgeon uses stitches to close the PFO . A PFO closure fills an opening between your heart's two upper chambers.Patent foramen ovale closure is a procedure to close a hole in the heart. We use minimally invasive approaches to treat PFO without open-chest surgery. A patent foramen ovale (PFO) is a hole in the heart that didn't close the way it should after birth. When the foramen ovale remains open, it is called a "patent foramen ovale" or PFO. Tip: Click an analysed process below to view more details. Learn more about the causes and complications of this condition in which a hole in the heart doesn't close the way it should after birth. The use of hydrogen peroxide can reveal or clarify an ante mortem tattoo.