A review of the existing literature showed that Le Moigne and colleagues found the rate of stroke in patients with PE and PFO was 21.4% 12, while Di Tullio and colleagues found that the rate of stroke in patients with PFO was 6.2% 10.
Results. A total of 19,005 adults with ASD/PFO closure were included, out of which 7785 (41%) had an isolated surgical approach and 11,220 (59%) had transcatheter approach from 2016-2019. Overall, 530 (2.79%) patients died (200 2.57% in surgical group and 330 2.94% in transcatheter group).
Possible Complications Some people may have a condition shortness of breath and low arterial blood oxygen levels when sitting or standing. This is called platypnea-orthodeoxia. This is rare. Rarely, people with PFOs may have a higher rate of a certain type of stroke (called paradoxical thromboembolic stroke).
If a PFO exists, a little blood can flow between the atria through the flaps. This flow is not normal. The condition is most important because it raises the risk for stroke. Blood clots can travel from the right atrium to the left atrium and out to blood vessels of the body.