A patent foramen ovale (PFO) is a hole in the wall between the heart's two upper chambers (atria). Before birth all babies have this opening.In this heart surgery, the surgeon uses stitches to close the PFO . In these patients, closure of PFO is an attractive goal. Patent foramen ovale closure is a procedure to close a hole in the heart. We use minimally invasive approaches to treat PFO without open-chest surgery. Paradoxical embolism through patent foramen ovale (PFO) may lead to ischemic stroke and transient ischemic attack (TIA). The foramen ovale is a hole in the wall between the left and right atria of every human fetus. This hole allows blood to bypass the fetal lungs. Patent foramen ovale closure is a procedure to close a hole in the heart.