Patent foramen ovale closure is a procedure to close a hole in the heart. We use minimally invasive approaches to treat PFO without open-chest surgery.In this heart surgery, the surgeon uses stitches to close the PFO . B) Five or more well placed stitches may do the job. C) AMPLATZER PFO occluder with a good potential for complete closure. A patent foramen ovale (PFO) is a hole in the heart that didn't close the way it should after birth. The medical term for this opening in the heart is a patent foramen ovale. (PFO). Patent foramen ovale and atrial septal defect closure is a routine procedure to close holes in the upper chambers of the heart. In about 1 out of 4 people, the opening never closes. If it does not close, it is called a PFO.