The majority of PFOs can be closed via minimally invasive or percutaneous catheter-based techniques. A patent foramen ovale (PFO) occurs when the flap-like opening does not close.A patent foramen ovale (PFO) is a hole in the heart that doesn't close. It can increase your stroke risk, but we offer highly effective treatments. The foramen ovale is a hole in the wall between the left and right atria of every human fetus. This hole allows blood to bypass the fetal lungs. A patent foramen ovale (PFO) is a hole in the heart that didn't close the way it should after birth. We sought to evaluate PFO closure rates and indications relative to the timing of regulatory approval and publication of key randomized trials. In this heart surgery, the surgeon uses stitches to close the PFO . Consent for Cookie Use We use cookies to improve your experience on our websites.