In this heart surgery, the surgeon uses stitches to close the PFO . A patent foramen ovale (PFO) is a hole in the heart that didn't close the way it should after birth.The foramen ovale is a hole in the wall between the left and right atria of every human fetus. This hole allows blood to bypass the fetal lungs. This document addresses the transcatheter closure of patent foramen ovale and transcatheter or open left atrial appendage (LAA) closure. Of note, the high end of the CI does rule out a clinically important benefit for aspirin.