In this heart surgery, the surgeon uses stitches to close the PFO . PFO treatment closes the Patent Foramen Ovale (PFO) through blood thinning medicines or a catheter-based procedure to close the hole.A PFO closure fills an opening between your heart's two upper chambers. A patent foramen ovale occurs when a hole that is always present in a newborn's heart fails to close as it should once the lungs begin to function after birth. The foramen ovale is a hole in the wall between the left and right atria of every human fetus. This hole allows blood to bypass the fetal lungs. The foramen ovale usually closes 6 months to a year after the baby's birth. Patent foramen ovale closure is a procedure to close a hole in the heart. We use minimally invasive approaches to treat PFO without open-chest surgery. It typically closes during infancy.