A PFO closure is a surgical procedure to close the hole that should have sealed on its own after birth. PFO is a flap-like opening in the heart between the upper chambers.The foramen ovale is a structure in the wall of the heart between the two upper chambers. Patent foramen ovale closure is a procedure to close a hole in the heart. We use minimally invasive approaches to treat PFO without open-chest surgery. In this heart surgery, the surgeon uses stitches to close the PFO . If you have a PFO and low blood oxygen levels or an unexplained stroke, you may need a procedure to close the hole. Patent foramen transcatheter repair is a procedure to fix this hole in the heart. Normally, the atrial septum separates the right and left atria. Patent foramen ovale (PFO) is a hole between your heart's upper chambers.