A PFO may permit blood clots to pass from the right side of the heart to the left side, possibly leading to a stroke. New data demonstrate the connection between closing a patent foramen ovale (PFO) and recurrent stroke reduction in select patients.Patent foramen ovale (PFO) or hole in the heart, affects millions of people and can cause a stroke. Some studies have found that patent foramen ovales (PFOs) are more common in people with unexplained strokes and migraines with aura. Stroke is the major possible complication of a PFO. People who have a PFO are slightly more likely to have a stroke than people who don't. This does not mean that everyone who has PFO will experience a stroke or mini-stroke. This does not mean that everyone who has PFO will experience a stroke or mini-stroke. However, it may cause serious complications under certain circumstances. Percutaneous closure of a patent foramen ovale (PFO) reduces the risk of recurrent cryptogenic stroke specifically in younger patients.