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Answer: Informed consent is required under federal research regulations for the protection of human subjects. The HIPAA Privacy rule, a different regulation, separately requires that patients give written Authorization before a covered entity may use or disclose patients' protected health information for research.PHI may be used and disclosed for research with an individual's written permission in the form of an Authorization. HIPAA allows for researchers to access and use PHI when necessary to conduct research. Permission to Use Private Personal Identifiable Health Information for Research. It is always preferred to obtain authorization to use an individual's PHI. Some research studies do not use, disclose or create PHI and are not subject to HIPAA regulations. If research participants sign an informed consent document, is this adequate to collect their PHI for research purposes? Research Using or Creating PHI of Living Individuals. HIPAA regulations allow researchers to access and use PHI when necessary to conduct research.