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Employee Stock Option Plan of Vivigen...

Vivigen

Name: Employee Stock Option Plan of Vivigen, Inc.
Brand: US Legal Forms
Price: 59.00 USD
Rating: 4.67 (367 reviews)

Category:

Corporations - Public - Stock Options

State:

Multi-State

Control #:

US-CC-18-148

Format:

Instant download

Description

18-148 18-148 . . . Employee Stock Option Plan which recognizes eight levels of responsibility within corporation and which provides that each eligible employee shall receive stock option to purchase that number of shares of corporation common stock that is equal to number derived by dividing option value corresponding to his or her level of responsibility by initial grant price (fair market value on date of grant) according to schedule which ranges from technical and administrative personnel levels one through four with option values from $1,250 through $5,000 to Chief Executive Officer level eight with option value of $100,000. Options are exercisable for up to (a) 50% of shares covered by option at any time after corporation's gross revenues meet or exceed a 30% increase for each of two consecutive calendar years ending following grant of option and (b) 100% of shares covered by option at any time after corporation's gross revenues meet or exceed a 40% increase for each of two consecutive calendar years following grant of stock option

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2.1. Osteoblasts. Osteoblasts are cuboidal cells that are located along the bone surface comprising 46% of the total resident bone cells and are largely known for their bone forming function 22.

ViviGen is a cellular allograft intended for repair or reconstruction of musculoskeletal defects. ViviGen is being utilized in fusion, nonunion, and malunion for foot/ankle or long bone trauma in patients with compromised biology.

In order to determine the presence of viable cells, ViviGen bone chips were thawed after processing and cryopreservation and were plated in culture wells. The cells were able to migrate from the bone chips and attach to the culture plate demonstrating that they survived the freezing and thawing process1 (Figure 2).

Cellular bone matrices (CBM) are allograft products that provide three components essential to new bone formation: an osteoconductive scaffold, extracellular growth factors for cell proliferation and differentiation, and viable cells with osteogenic potential.

Demineralized bone matrix (DBM) is allograft bone that has had the inorganic mineral removed, leaving behind the organic "collagen" matrix.As a result of the demineralization process, DBM is more biologically active than undemineralized bone grafts; conversely the mechanical properties are significantly diminished.

ViviGen is a Human Cells, Tissues, and Cellular and Tissue-based Product (HCT/P) comprised of cryopreserved viable, lineage committed bone cells within a corticocancellous bone matrix and demineralized bone delivering all three properties necessary for bone formation.

DBM Putty is composed of Demineralized Bone Matrix and sodium hyaluronate. The demineralized bone allograft in this product is prepared from tissue procured from a deceased donor using aseptic surgical techniques.Sodium hyaluronate is a naturally derived material that is biocompatible and biodegradable.

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What type of cells are preferred for bone formation?

What is a ViviGen bone graft?

What demonstrates that cells within ViviGen survive cryopreservation and thaw?

What is cellular bone matrix?

What is DBM allograft?

What type of product is ViviGen?

What is DBM Putty?

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