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Variant annotation is a crucial step in linking sequence variants with changes in phenotype.Incorrect or incomplete annotations can cause researchers both to overlook potentially disease-relevant DNA variants and to dilute interesting variants in a pool of false positives.

Functional annotation is the process of attaching biological information to sequences of genes or proteins. The basic level of annotation is using sequence alignment tool BLAST for finding similarities, and then annotating genes or proteins based on that.

Writing Annotations An annotation is a brief note following each citation listed on an annotated bibliography. The goal is to briefly summarize the source and/or explain why it is important for a topic. They are typically a single concise paragraph, but might be longer if you are summarizing and evaluating.

Underlining and HighlightingUnderlining or highlighting is the most straightforward method of annotation, as well as the least engaging. Marking certain words, phrases or sentences with a highlighter, pen or pencil can quickly identify key concepts of any text.

Edit notes1.In the transcript viewer, click the note that you want to edit. The Annotation dialog box appears.Click the Notes tab and locate the specific note or reply that you want to edit.Click Edit.Change the text and formatting, as necessary.Click Save. The edited note appears on the Notes tab.Click Close.

A reader might annotate a book, paper, pamphlet. or other texts for the following reasons: a student noting important ideas from the content by highlighting or underlining passages in their textbook. a student noting examples or quotes in the margins of a textbook. a reader noting content to be revisited at a later

A simple method of gene annotation relies on homology based search tools, like BLAST, to search for homologous genes in specific databases, the resulting information is then used to annotate genes and genomes.