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Sustained release (SR) One example of this is Calan SR (verapamil ER), which is dosed once daily, whereas the immediate-release form is dosed 3 times daily. However, even though the medication is released over a longer period of time, it doesn't mean the medication levels remain constant while it's in your body.

Extended-release dosage consists of either sustained-release (SR) or controlled-release (CR) dosage. SR maintains drug release over a sustained period but not at a constant rate. CR maintains drug release over a sustained period at a nearly constant rate.

Sustained release allows delivery of a specific drug at a programmed rate that leads to drug delivery for a prolonged period of time (Moghimi et al., 2001). This approach of drug release is especially useful for drugs that are metabolized too fast and are eliminated from the body shortly after administration.

A repeat-action tablet is a type of modified-release drug product that is designed to release one dose of drug initially, followed by a second dose of drug at a later time. A prolonged-action drug product is designed to release the drug slowly and to provide a continuous supply of drug over an extended period.

Controlled-release formulations guarantee sustained release of a drug in a modulated or contained pattern, thereby facilitating the availability of the drug over a prolonged period to provide therapeutic action.

Controlled release (CR) CR medications release the active ingredient(s) at a specific rate to keep constant medication levels in your body for a specific time period. This allows for more precise control of medication levels after taking it and fewer doses needed throughout the day.

These systems introduced the following advantages compared with other methods of delivery: (1) the possibility of maintaining plasma drug levels in the optimal therapeutic range, (2) the eventuality to remove or decrease damaging side effects from systemic drug delivery by the local administration from a controlled