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For each of the twelve biomarkers, an individual received a score of 1 if their biomarker level was more extreme than the high-risk cutoff, and 0 otherwise. The allostatic load sum-score was calculated by taking the sum of all twelve biomarker scores. Thus, the allostatic load sum-score can range from 0 to 12.

Purpose: The weathering hypothesis states that chronic exposure to social and economic disadvantage leads to accelerated decline in physical health outcomes and could partially explain racial disparities in a wide array of health conditions.

Posited by Geronimus (1992), the weathering hypothesis states that stress, resulting from social adversity, wears the body down and ages it prematurely, resulting in dis- eases and consequences of aging appearing earlier than one would expect at a given chronological age.

The weathering hypothesis was initially proposed as a sociological explanation for health disparities, but it is closely related to biological theories like the allostatic load model, which proposes that an individual's exposure to repeated or chronic stress over their lifetime has physiological consequences which can ...

Abstract. Introduction: Allostatic load refers to the cumulative burden of chronic stress and life events. It involves the interaction of different physiological systems at varying degrees of activity. When environmental challenges exceed the individual ability to cope, then allostatic overload ensues.

Geronimus coined a term for this chronic stress ? she calls it "weathering," which, she says, "literally wears down your heart, your arteries, your neuroendocrine systems, ... all your body systems so that in effect, you become chronologically old at a young age." She writes about the phenomenon in her new book, ...

For Black moms, younger age is linked to better maternal and infant outcomes. Geronimus theorized that is because of the concept of weathering; Black women experience ?earlier onset of unfavorable physical health conditions? because they are chronically exposed to racism and discrimination.